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Sensitivity analysis reveals the degree of robustness of the results as follows ( Supplementary Figures S3, S4 ): i) Primary outcome & secondary outcomes (nonfatal stroke, all-cause death, HF hospitalization): Excluding any single study did not alter the direction and magnitude of effects, confirming robustness
Temperature excursions above 25C for more than two hours cause irreversible peptide fragmentation that cannot be detected visually but renders the solution pharmacologically inactive
Additionally, experts advise discontinuing dipeptidyl peptidase-4 inhibitors when initiating GLP-1 therapy, as both act on similar pathways
Revised: 1/2026 Full Prescribing Information WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures
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