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Liquids and multi-dose bottles are particularly vulnerable
Infertility can also occur in individuals with insufficient B12
Approval rates range from 53% to 82% depending on how thoroughly the provider documents medical necessity
In the key Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron 36 mg produced mean body weight reductions of 11.2% at 72 weeks in adults with obesity, with nearly 55% of participants achieving at least 10% weight loss and 36% achieving 15% or more
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