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Research indicates that significant caloric restriction triggers compensatory mechanisms including decreased resting metabolic rate, reduced non-exercise activity thermogenesis (NEAT), and hormonal changes that promote energy conservation

In a clinical trial of the Wegovy pill in people without diabetes, people taking a 25 mg dose lost about 6% of their body weight in three months

They received once-weekly subcutaneous injections of either 5 mg, 10 mg, or 15 mg of tirzepatide or a placebo over a period of 40 weeks

Those in the top quarter of Total Antioxidant Capacity (TAC) in their diet have halve the risk, in study on 2,716 people over age 60