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have proposed that the impacts of Frag 176-191 on enzymes such as HSL and acetyl-CoA carboxylase may be linked to intracellular signaling mechanisms involving the biphasic release of DAG, similar to that observed with GH
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In these individuals, the fractional excretion of urate approaches 150%, highlighting the predominant mechanism of tubular urate secretion in the absence of reabsorption
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