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Targeting cartilage breakdown by reducing catabolic enzyme activity is an important strategy for treating or modify the course of OA 55
Several drugs are currently in advanced clinical trials: Phase III Clinical Trials: IBI362 (Innovent/Eli Lilly), CagriSema (Novo Nordisk), Retatrutide (Eli Lilly), and Survodutide (Boehringer Ingelheim)
These differences in structural plasticity or rigidity among the three receptors give clues to further optimize unimolecular agonists using complementary amino acids to target common regions of individual receptors and distinct sequences to confer receptor selectivity
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