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Pramlintide is a short-acting amylin analog, which cagrilintide already covers as a long-acting version
available human data consist of a small number of low-quality, small-sample-size studies, and no large-scale randomized controlled trials have been published to date [4]
Researchers comment that a single introduction of the peptide may upregulate growth hormone production by somatotrophs for prolonged periods of time, thus apparently contributing to an overall increase in [growth hormone] secretion by 46% and also potentially upregulating its main anabolic mediator insulin-like growth factor-1 (IGF-1) by 45% on average
doi: 10.1093/INFDIS/JIAC136 172 KhuntiKDaviesMJKosiborodMNNauckMA
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