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Description

Data are plotted as means SD, n = 4 biologically independent samples

At 24 weeks, retatrutide (1 mg, 4 mg, 8 mg or 12 mg) met the primary endpoint for efficacy in participants with obesity or overweight without diabetes

Tirzepatide can typically be continued with monitoring

These interaction patterns indicate pathway-level connectivity rather than isolated metabolite changes and support the involvement of amino acid and polyamine metabolism in ASD-associated metabolic alterations