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FDA sorts nominated bulk substances into categories while it works through the review process: Category 1 under evaluation
GLP-1 patches remain primarily investigational, with limited FDA-approved options currently available
Limited data exists for: Understudied Populations: Adults over 75 years (increased sensitivity to appetite suppression) Adolescents (ongoing development considerations) Individuals with BMI under 27 (insufficient safety data) Pregnant or lactating individuals (no safety data) Individuals with significant psychiatric conditions Gender Considerations: Research suggests some metabolic peptides may show differential effects between males and females, though data for cagrilintide and retatrutide specifically remains limited
doi: 10.4236/abc.2022.124011 74 El MoussawiLH
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