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If you are switching from tirzepatide to retatrutide , allow an appropriate washout period and start retatrutide at the beginning of its titration schedule rather than jumping to a dose equivalent to your tirzepatide dose

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Central 5-HT systems also play an important role in the suppression of feeding

Effect of truncated glucagon-like peptide-1 [proglucagon-(78107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach