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A lower dose may help maintain baseline antioxidant levels, while a higher dose is often needed when: Oxidative stress is high Skin dullness or uneven tone is more visible You want noticeable skin benefits Environmental exposure (pollution, sun) is high This is where the difference between 100 mg and 1000 mg becomes important
Treat it like the drug that it is and only take it if necessary
Some evidence: A randomized controlled study with 250 mg/day (reduced or oxidised form) over 12 weeks found that melanin index and UV-spots tended to be lower vs placebo
The appearance of mild-yellowish, mosaic symptoms was associated with a dramatic, 20-fold induction of defense-related genes like PR-1, chitinase and GST (Niehl et al., 2006)
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