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Reactive nitrogen species production is also induced by the increase of Ca 2+ influx and oxide nitric synthase activity (Brown and Yamamoto, 2003)

Although no current evidence suggests that GLP-1RAs induce -catenin mutations or APC deficiencies, it is hypothesized that prolonged use of GLP-1RAs may foster the proliferative progression of colorectal cancer cells and pancreatic -cells, based on their mechanisms of action [99]