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NRF2 reprograms cellular metabolism to funnel metabolic intermediates into antioxidant pathways While NRF2 regulates the expression of antioxidant and NADPH-generating enzymes, metabolic intermediates are required to support these pathways

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Human studies remain limited, but epidemiological data suggest chronic acetaminophen use is associated with increased oxidative stress biomarkers and, in vulnerable populations, liver enzyme elevation

Glutathione is produced inside every cell in the human body, and is most highly concentrated in organs like the pancreas, kidneys, and liver