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The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) (20)
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Furthermore, recent research indicates that TGR5, expressed in pancreatic and -cells, promotes insulin secretion and stabilizes glucose levels (Kumar et al., 2012, 2016)
a unique identifier number, age group (age groups: 85 years old, 6584, 1864 and 1217 years, non-specified age), sex, date of reporting, origin of the report (EU or non-EU), reporters profession (healthcare professional or non-healthcare professional), concomitant conditions and psychotic ADR outcomes and seriousness
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