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While GLP-1s have, for years, been a prescribed treatment for type 2 diabetes, they now are an FDA-approved weight-loss drug that also reduce the risk of certain cancers, heart disease, cognitive decline and more

Furthermore, semaglutide is superior to other GLP-1R agonists, such as liraglutide, which uses similar pharmacological mechanisms but only has a half-life of 13 h and therefore has to be injected subcutaneously daily

Sometimes, it's patients who need the GLP-1 agonist for diabetes management but can't afford to lose too much weight, she said

The cardiovascular and renal benefits of GLP-1 drugs are real and now well documented in outcome trials, but the receptor biology behind them is more indirect than it first appears