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Drug Interactions and Safety Considerations Orlistat does not have known major pharmacokinetic interactions with tirzepatide because orlistat remains in the gut lumen and tirzepatide acts systemically
Combined with your medical history, baseline GI function, and current medication profile, genetic context can support a more informed discussion about whether slower titration, lower target doses, or additional GI support strategies are appropriate for you
Supplementary Table 15)
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