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A meta-analysis of adults with knee OA and obesity found that a 5% to 10% weight loss significantly improved pain, self-reported disability, and physical quality of life ( 5.4 Positioning GLP-1 receptor agonists among obesity-treatment options GLP-1 receptor agonists should be positioned within the broader continuum of obesity treatment rather than presented as a replacement for existing strategies
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GLP-1 receptor agonists are lab-developed compounds that mimic GLP-1 action at receptors
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