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Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use
This multi-receptor mechanism distinguishes it from existing approved therapies such as semaglutide or tirzepatide, and it is this broad pharmacological activity that underpins both its therapeutic potential and its side effect profile
Tin Wui Wong Lijing Wang College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu, Peoples Republic of China Correspondence: Lijing Wang, College of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, Peoples Republic of China, Tel +86 182 860 69474, Email [email protected]
Zhang Y, Xiao A, Zheng T, Xiao H, Huang R
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