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In the pancreas, semaglutide stimulates insulin secretion in a glucose-dependent manner meaning it triggers insulin release when blood glucose is elevated, but not during normoglycemia, which substantially reduces the risk of hypoglycemia compared to older antidiabetic agents
This chemical modification binds the peptide to albumin in the blood, significantly extending its half-life and allowing stable GH pulses for days , rather than minutes
Also helpful if you're sensitive to higher protein meals
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