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The simple answer is because they can. In 2024 alone, Novo Nordisk pulled in over $26 billion from Ozempic and Wegovy
In summary, supplementing GLP-1 RA-induced weight loss with simultaneous blockade of GDF8 and ActA can increase lean mass and muscle, yielding increased fat loss and widespread metabolic benefits and thus improving the quality and functional response to GLP-1 RA-induced weight loss
This clinical improvement correlated with upregulation of anti-inflammatory IL-10 and concurrent downregulation of the pro-inflammatory cytokines TNF- and IL-1 (251)
