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The hypothalamus has also been implicated as a major center for mediating the pharmacological effects of GLP-1R action on energy metabolism
Observational studies suggest that GLP-1RA therapy may be associated with changes in musculoskeletal parameters under conditions of rapid weight loss [34, 40]
Furthermore, it has been shown that 2472 hour zero-calorie fasting causes liver mitochondrial oxidative stress in rats by increasing mitochondrial free radical leak and reactive oxygen species (ROS) generation at complex III level in vivo studies [45, 46]
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