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These three tiers are generally consistent: certainty of benefit is concentrated in phenotypes related to body weight and central obesity, whereas conclusions regarding IR and reproductive outcomes are more dependent on study design and patient phenotype
At this time, there is no clinical evidence showing that over-the-counter GLP-1 patches produce the same appetite or weight loss effects as prescription GLP-1 medications
However, GI side effects are common during titration, with nausea, vomiting, and diarrhea increasing at higher doses, and discontinuation rates as high as 25% at the 15 mg level
Setting: The treatment must be done in a proper hospital or clinic setting under the supervision of a healthcare professional
