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Several meta-analyses in various diabetic populations have found that SGLT2 inhibitor treatment is associated with reduced risk of dying from any cause (Garber 2020)
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Our interpretation of the biological relevance of our effect size estimates is further supported by several laboratory studies showing that when protein carbonyls accumulate, they tend to aggregate and can lead to cell death, tissue injury and development of disorders 33,34
Previous clinical and preclinical studies have been contradictory, says co-corresponding author Yonggui Yuan of Southeast University in Jiangsu, China
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