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Staff cited inadequate substance characterization, uncertain product quality, insufficient evidence of effectiveness for ulcerative colitis, sparse human safety data, and unresolved risks such as immunogenicity, aggregation, impurities, and long-term exposure

The activated oxygen role of peroxisomes in senescence

These changes lead to an overall increased permeability of the BBB and imbalance of the CNS microenvironment, as well as the potential introduction of pathogens and neurotoxins into the brain that can contribute to neurodegenerative processes (Funk et al., 2021

Studies have shown that IF significantly enhances GH secretion and elevates insulin-like growth factor binding protein 1 (IGFBP1) levels up to fivefold [42], thereby modulating IGF-1 bioavailability and enhancing autophagy, lipolysis, and muscle preservation [42, 43]