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The standard schedule steps up about every four weeks, so the full climb from the starter dose to the maximum takes at least 20 weeks

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Numerous toxicity studies have been done to assess the safety of MSM and doses up to 4,845.6 mg per day (4.8 grams) appear to be safe ( However, some people may experience mild reactions if they are sensitive to MSM, such as stomach issues like nausea, bloating and diarrhea

In animal models, GIP agonists were shown to have beneficial effects on tissue-level bone material properties