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242 The function of immune cells infiltrating tumor cells can also be suppressed, preventing them from exerting their typical effects
Apart from nuclear localization, the hinge region, and in particular its 629-RKLKKL-634 motif, was also found to play a complex role in DNA binding, coactivator recruitment, and N/C interaction 55,56 and is a target site for acetylation, ubiquitylation and methylation 56
This happens because BPC-157 improves VEGFR2 internalization and activation without needing other known ligands
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