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This comprehensive analysis confirmed substantial reductions in hepatic fat content measured by MRI-PDFF (weighted mean difference -5.8%, 95%CI: -7.1% to -4.5%), liver enzymes, and histological parameters including steatosis and inflammation scores
Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk
Regular moderate exercise supports hormonal balance, though excessive exercise combined with rapid weight loss can exacerbate menstrual irregularities
The oral obesity drugs are set to grow commercially due to their greater convenience compared to injectable forms, which minimize issues such as fear of needles, the complexity of administering injections, and weariness from continued use
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