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The 2026 EASO pharmacotherapy update formalised this evidence by ranking tirzepatide above semaglutide for obesity management, while simultaneously supporting semaglutide as the better-documented agent for liver fibrosis improvement in metabolic dysfunction-associated steatohepatitis (MASH), based on more mature phase 3 ESSENCE trial data [1]
This usually improves as nutrition stabilizes and the body adapts to treatment
Less water means smaller injections and longer vial life, but higher risk of measurement errors
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