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also showed that miR-146a levels were upregulated in the vitreous humor (VH) and serum of UM patients, which could have a regulatory role in UM melanocyte surveillance (75)

Eloralintide is investigational and is not FDA-approved

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The mechanism proposed involves chromatin remodeling at the hTERT promoter specifically, a reduction in the repressive histone modifications (H3K9me3, H3K27me3) that maintain transcriptional silencing in somatic cells allowing activating transcription factors to access promoter binding sites and initiate hTERT transcription