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Dose adjustment is not recommended in patients with mild-severe renal impairment (eGFR = 15-89 mL/min/1.73 m 2 ), but use is not recommended for patients with end-stage renal disease (127)

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As with any investigational substance, unknown or idiosyncratic responses cannot be excluded, and the long-term safety of BPC-157 has not been formally characterised

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