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A large portion of off-market GLP-1 content used harmful messaging about weight loss and appearance, included sexual imagery, or made false claims about women's health, according to the researchers

Emerging human data, including small pilot studies showing good tolerability (e.g., intravenous infusions up to 20 mg with no adverse effects) and subjective improvements in conditions like chronic knee pain, further support its promise

However, extrapolating these findings to human physiology is problematic due to significant species differences in pancreatic anatomy, GLP-1 receptor distribution, and metabolic responses