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In the ACHIEVE-3 head-to-head trial published in The Lancet in February 2026, orforglipron 36 mg delivered 73.6% greater relative weight loss than oral semaglutide (14 mg) in people with type 2 diabetes 9.2% body weight loss vs
*nutrient reference values Fibersol is a registered trademark of Matsutani Chemical Industry Co., Ltd
A healthy diet and regular exercise remain foundational components of a successful weight loss plan
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