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Therefore, VUS should only be considered for reporting to clinicians when there is a high level of supporting evidence and additional evidence might be obtained to allow reclassification as (likely) pathogenic (e.g
[76]B.N
The triple-agonist mechanism provides unique research value that cannot be replicated by combining other single or dual-agonist compounds
[15] [16] The hypothalamic-pituitary-adrenal (HPA) axis tightly regulates cortisol production, and disruptions to this system can result from chronic stress, certain medications, tumours, or autoimmune conditions
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