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Particularly in advanced or metastatic cancer, a hypoxic TME is frequently established and plays a pivotal role in cancer progression

Consequently, it has been studied for wound healing, anti-inflammation, and skin rejuvenation

The following biomarkers were analyzed according to reports in the literature: ANGIPOIETIN-1, ANGIPOIETIN-2, BDNF, EGF, EOTAXIN, FAS LIGAND, FGFbasic, G-CSF, GDNF, GM-CSF, IFNy, IL-10, IL-12p40, IL-12p70, IL-15, IL-16, IL-17A, IL-1B, IL-1ra, IL-2, IL-22, IL-4, IL-5, IL-6, IL-7, IL-8, IP-10, LIF, LT-alpha, MCP-1, MIF, MIP-1, MIP-1B, MMP-9, OSTEOPONTIN, PDGF-AB, PDGF-BB, RANTES, SCF, SDF-1, TGF1, TGF2, TGF3, TNF, TRAIL and VEGF-C

Int J Med Sci