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The database may not capture clinical events that occur outside of participating healthcare networks, which could lead to undercounting of certain outcomes.They also noted that certain demographic groups, including low-income individuals and Black and Hispanic individuals, are less likely to be prescribed GLP-1 receptor agonists, and that patients who receive these medications may have greater access to healthcare in general

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These interactions may reduce the efficacy of drugs like oral contraceptives and alter the absorption of medications such as digoxin and statins, necessitating careful monitoring and adjustments

Weight loss is the key driver for these effects