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Nrf2/Keap1/ARE Redox Regulatory Pathway In response to oxidative or xenobiotic stress, Nrf2 dissociates from its inhibitor Keap1, translocates to the nucleus, and binds antioxidant response elements (ARE) to induce expression of genes involved in antioxidant defense and GSH biosynthesis (41)
IV glutathione has better absorption but requires recurring clinic visits and comes at higher cost
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As everybody is different in terms of metabolism, absorption, and oxidative stress patterns, glutathione may react differently when taken at different times
