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Human longevity outcomes have not been established in large scale Western trials
Dosing protocols Phase 2 clinical trials used a titration schedule starting at 0.5mg weekly, escalating through 1mg, 2mg, 4mg, 8mg, and reaching maintenance doses of up to 12mg weekly over several months
Chemistry Review for NDA 213051: Rybelsus (semaglutide)
In clinical trials, constipation was not more common at higher doses
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