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Orlistat, a lipase inhibitor that reduces fat absorption, represents an alternative pharmacological option with a different mechanism of action, though it also carries gastrointestinal side effects including oily or fatty stools
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An impaired incretin effect can cause all sorts of issues that could make it harder for you to lose weight, such as: Insulin resistance: This occurs when your body no longer responds to insulin adequately, which can lead to increased blood glucose (sugar) levels over time because the insulin doesnt transport enough glucose to cells in your muscles and organs to be used for energy (3)
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