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Quick dramatic changes more likely indicate inflammatory response than genuine improvement
10.1016/j.neuroscience.2007.08.028 110 Vzquez-MezaH.Vzquez-MezaH.Vilchis-LanderosM
Thirdly, the recommended amount of B12 replacement therapy is based on a study that began in 1947 on just seven individual patients 7
However, a recognised limitation of these therapies is that up to 40% of the weight lost may come from lean mass, which includes skeletal muscle and connective tissue
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