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Notably, the STEP (Semaglutide Treatment Effect in People with obesity) trials, which specifically examined body composition, demonstrated substantial weight loss compared with placebo (NCT03548935) [53], and reductions in fat mass and visceral adipose tissue were accompanied by decreases in lean mass, although the proportion of lean mass relative to total body mass increased (NCT04074161) [54]
Thus, the residues forming the dimeric interface should also constitute a good criterion for distinguishing monomeric from dimeric proteins
NHS funding for Saxenda is restricted to specialist tier 3 weight management services under NICE guidance
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