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Eli Lilly plans to submit a Biologics License Application (BLA) not an NDA, since retatrutide is a biologic in Q1 2027, following completion of all four core TRIUMPH trials in 2026

The difference with GLP-1 medications is the number of people affected

In the Redox Biology study described earlier [5], individuals with type 2 diabetes treated with GLP-1 receptor agonists demonstrated reduced ROS production, restoration of mitochondrial membrane potential, improved oxygen consumption, and lower levels of myeloperoxidase (MPO)