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Despite these therapies not being initially designed to trigger cellular senescence, it was discovered as early as 1998 that cisplatin could induce cellular senescence in head and neck cancer cells [53]

5-amino-1-methylquinolinium injection also upregulates GLUT4 (glucose transporter 4) expression, promoting glucose transport into adipose and muscle cells and reducing blood glucose accumulation

Whether or not that framing fully resolves the regulatory picture, it is the lens he uses for everything that follows

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