As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5
Risks and side effects Despite containing natural or herbal ingredients, these commercial GLP-1 patches are not approved by the U.S
They also have a role in diabetic neuropathies, a side effect of diabetes that damages the brain[11]
Zepbound is an FDA-approved, once-weekly injectable GLP-1 medication for chronic weight management, authorized in October 2023