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Some phenotypes plausibly need a slower-than-label climb: lighter bodies (higher exposure per milligram), a history of severe GLP-1 gut intolerance, a high baseline heart rate, or a lean, low-reserve build
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Structural repair takes significantly longer, typically 2 to 6 months for meaningful tissue remodeling
The clinical data does not show tolerance development in the way that some other medications lose effectiveness over time
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