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One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)

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Although numerous previous reviews have explored metabolic reprogramming in cancer, most have predominantly focused on glycolysis or broad metabolic alterations common across multiple tumor types