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pylori activates pattern recognition receptors like NOD1/NOD2 [168], further stimulating inflammatory signaling pathways such as MAPK and NF-B [149]
Ex-4 inhibits mTOR, an autophagy inhibitor in tumor cells, by downregulating Akt and simultaneously activating AMPK, subsequently attenuating the phosphorylation of its major downstream targets, eukaryotic translation initiation factor 4e binding protein 1(4E-BP1) and ribosomal s6 kinase 1(S6K1)
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doi: 10.1172/JCI196346
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