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Eur J Med Chem 80:175183 Nasir Abbas Bukhari S, Jantan I (2015) Synthetic curcumin analogs as inhibitors of -amyloid peptide aggregation: potential therapeutic and diagnostic agents for Alzheimers disease

Clinical-trial data shows that most patients regain most of the weight lost while on GLP-1s when they stop taking the drugs

2 This effect tends to be more severe with shorter-acting GLP-1 RAs

This finding highlights a fundamental distinction that must be applied when interpreting the preclinical literature as a whole: the majority of studies reporting positive outcomes employed a preventive or co-treatment paradigm, in which the drug was administered prior to or concurrently with pathological induction