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This result suggests that ATP from L-cells acts as a neurotransmitter, capable of activating local nerve endings expressing purinergic receptors such as the sensory vagal afferent neurons of the nodose ganglion, which we found by qPCR and immunostaining to express P2rx3
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Using liraglutide (Lira) as a model GLP-1 receptor agonist, these NPs effectively alleviated diabetic symptoms in db / db mice [176]
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