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GLP-1 microdosing uses sub-therapeutic doses (0.05-0.25mg semaglutide weekly vs standard 0.25-2.4mg) to minimize gastrointestinal side effects while achieving mild appetite suppression
To enable the continuous online monitoring of genetically-encoded probes, an in-house coupled fermentor-fluorimeter system was previously developed 34
By contrast, peptides such as PYY and apelin were discontinued primarily due to formulation limitations or tolerability at supraphysiologic dosespharmacologic rather than biological failuresand therefore meet criteria for re-evaluation
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