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Similar content being viewed by others Introduction One rare neurodegenerative disorder with an autosomal recessive inheritance pattern is Wolfram syndrome (WS), which is caused by biallelic mutations of the Wolframin ER transmembrane glycoprotein (Wfs1) gene and first manifests as diabetes mellitus, followed by optic nerve atrophy, deafness, and symptoms of neurodegeneration 1,2,3

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