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But in practice, and especially with regard to synthetic and recombinant peptide forms, there are some considerable potential safety concerns: Immunogenicity Most notably, per a 2020 assessment on therapeutic peptide safety, synthetic and recombinant peptides pose the risk of immunogenicity the ability of a substance to provoke an immune response.15 An immunogenicity-inducing peptide, when introduced to the body, would cause the bodys immune system to perceive the peptide not as a medication but as a threat
Recapitulating the human condition, SKO mice displayed significantly enlarged livers when compared to WT controls ( Figure 3A ) ( Figure 3B )
Notably, our observation that GLP1-E2 stabilises beta cell identity and alleviates stress parallels earlier findings, where GLP1-E2 promoted redifferentiation and functional recovery of dedifferentiated beta cells in the streptozocin model, underscoring its potential as a beta cell restorative agent beyond glycaemic control [47]
Murphy JA, et al
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